About Longevity

What does Longevity mean?

Longevity is not only about living longer (lifespan), but also about staying healthy and active while aging (healthspan).

The goal is to maximize the years of life in good health – with energy, independence, and quality of life.

Livespan vs. Healthspan

Lifespan: The total number of years lived.
Healthspan: The years lived without chronic diseases, pain, or severe limitations.

Many people today reach an advanced age – but often spend the last years struggling with illness. Longevity research aims to close this gap.

The “Hallmarks of Aging”

The 9 Hallmarks of Aging

Genomic instability – accumulation of DNA damage

Over time, our DNA becomes damaged by stress, toxins, and imperfect repair processes. These mutations increase the risk of cancer and weaken cell function.

Telomere attrition – shortening of protective chromosome ends

Telomeres act like caps at the ends of chromosomes. With each cell division, they get shorter. When they become too short, the cell can no longer divide.

Epigenetic alterations – genes switched on or off incorrectly

Chemical changes to DNA (like methylation) change how genes are expressed. With age, the balance is lost: protective genes are silenced, harmful ones are activated.

Loss of proteostasis – proteins misfold and clump

Proteins need to fold correctly to work. Aging cells lose this ability, leading to toxic clumps. This is linked to diseases such as Alzheimer’s and Parkinson’s.

Deregulated nutrient sensing – cells react poorly to signals

Cells sense nutrients and hormones (like insulin) to regulate growth and repair. With age, this system becomes imbalanced, driving faster aging and metabolic diseases.

Mitochondrial dysfunction – the cell’s “power plants” lose efficiency

Mitochondria generate cellular energy. With age, they become less efficient, producing harmful free radicals and lowering energy supply.

Cellular senescence – old cells stop dividing but do not die

Some cells stop dividing but remain alive, releasing inflammatory molecules. This “zombie cell” effect damages surrounding tissue and accelerates aging.

Stem cell exhaustion – less regeneration and repair

Stem cells maintain and repair tissues. With age, their number and function decline, leading to slower healing and organ deterioration.

Altered intercellular communication – more inflammation, weaker immunity

Aging disrupts how cells and organs communicate. The result is chronic low-grade inflammation (“inflammaging”) and a weaker, less coordinated immune system.

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Built at the intersection of biology and technology.